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PETBioNewsNewsNo premature ageing in clones of clones

BioNews

No premature ageing in clones of clones

Published 9 June 2009 posted in News and appears in BioNews 76

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BioNews

Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour).
CC BY 4.0
Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false-coloured cryogenic scanning electron micrograph).

A team of researchers based at the University of Hawaii has shown that the ageing process is not accelerated in successive generations of cloned mice. Earlier studies carried out on Dolly the sheep indicated that cloned animals might age prematurely. But the US scientists, who published their results in last...

A team of researchers based at the University of Hawaii has shown that the ageing process is not accelerated in successive generations of cloned mice. Earlier studies carried out on Dolly the sheep indicated that cloned animals might age prematurely. But the US scientists, who published their results in last week's Nature, found that six generations of sequentially cloned mice aged normally.


The mice were cloned using SCNT (somatic cell nuclear transfer), the same technique used to create Dolly. Each time a cell divides to make two new cells, the ends of its chromosomes (telomeres) become shorter, until they become so short that the cell dies. But while Dolly's telomeres are shorter than expected for her age, those of the cloned mice are slightly longer than normal. Teruhiko Wakayama, who led the team, is not sure why the telomeres are longer, or if the mice will have a longer lifespan than normal.


The fifth generation mouse lived to be middle-aged, but the sixth generation clone was eaten by its foster mother, bringing the experiment to an abrupt end. 'It is a preliminary but very important study that needs to be repeated' said Tony Perry, another member of the team.

Related Articles

Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour).
CC BY 4.0
Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false-coloured cryogenic scanning electron micrograph).
News
9 June 2009 • 2 minutes read

Second generation 'recloned' bull doing well

by BioNews

A bull cloned from the clone of a prize-winning animal four years ago is healthy and fertile, Japanese researchers announced last week. The second generation clone was created using a skin cell, taken from a first generation clone when the animal was only four months old. The research, published in...

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