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PETBioNewsNewsART study shows possible link to hereditary condition

BioNews

ART study shows possible link to hereditary condition

Published 9 June 2009 posted in News and appears in BioNews 184

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BioNews

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.

A new study suggests that children born as a result of assisted reproduction technologies may have a greater risk of particular hereditary birth defects than children who are naturally conceived. A team of researchers from Johns Hopkins University and the University of Washington in the US studied a national registry...

A new study suggests that children born as a result of assisted reproduction technologies may have a greater risk of particular hereditary birth defects than children who are naturally conceived.


A team of researchers from Johns Hopkins University and the University of Washington in the US studied a national registry of 65 children with Beckwith-Wiedemann syndrome, a rare hereditary overgrowth disorder that can cause cancer and developmental malformations in children. Seven of the children were conceived using assisted reproduction technology and five of these had specific chromosomal mutations on chromosome 11 with a known link to the syndrome.


The authors of the study, which will be published in the January 2003 edition of the American Journal of Human Genetics, concluded that children born after assisted reproduction technology had a six-fold increase in the likelihood of developing Beckwith-Wiedemann syndrome than other children. They found that the risk rose from one in 15,000 births to one in 2,500 births if assisted reproduction technologies were used.


Lead author Dr Andrew Feinberg said that couples with fertility problems should not avoid treatment if they wanted to have a child, but added that additional research was required: 'this analysis should not affect people's decisions about whether to have IVF (in vitro fertilisation), because our findings still need to be validated'. Dr Roger Gosden of the Jones Institute for Reproductive Medicine in Virginia, US, said that further studies could show whether the higher incidence of the condition recorded in this study was the result of using assisted reproduction technologies rather than coincidence.

Related Articles

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
9 June 2009 • 1 minute read

Link between IVF and rare syndrome confirmed

by BioNews

An Australian study of 37 babies born with Beckwith-Wiedemann Syndrome (BWS) adds to the evidence linking in vitro fertilisation (IVF) and the condition. The researchers, from Murdoch Childrens Research Institute in Melbourne, looked at 37 babies born with BWS. They found a birth prevalence of one in 4000 in children...

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