PET PET
  • My Account
  • Subscribe
Become a Friend Donate
  • About Us
    • People
    • Press Office
    • Our History
  • Get Involved
    • Become a Friend of PET
    • Volunteer
    • Campaigns
    • Writing Scheme
    • Partnership and Sponsorship
    • Advertise with Us
  • Donate
    • Become a Friend of PET
  • BioNews
    • News
    • Comment
    • Reviews
    • Elsewhere
    • Topics
    • Glossary
    • Newsletters
  • Events
    • Upcoming Events
    • Previous Events
  • Engagement
    • Policy and Projects
      • Resources
    • Education
  • Jobs & Opportunities
  • Contact Us
  • About Us
    • People
    • Press Office
    • Our History
  • Get Involved
    • Become a Friend of PET
    • Volunteer
    • Campaigns
    • Writing Scheme
    • Partnership and Sponsorship
    • Advertise with Us
  • Donate
    • Become a Friend of PET
  • BioNews
    • News
    • Comment
    • Reviews
    • Elsewhere
    • Topics
    • Glossary
    • Newsletters
  • Events
    • Upcoming Events
    • Previous Events
  • Engagement
    • Policy and Projects
      • Resources
    • Education
  • Jobs & Opportunities
  • Contact Us
  • My Account
  • Subscribe
  • Privacy Statement
  • Advertising Policy
  • Thanks and Acknowledgements
PETBioNewsNewsNew guidelines published for the reporting of genetic risk prediction studies

BioNews

New guidelines published for the reporting of genetic risk prediction studies

Published 17 October 2012 posted in News and appears in BioNews 600

Author

Dr Sarah West

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.

This week saw the culmination of an international effort to devise guidelines to strengthen and standardise the reporting of genetic risk prediction studies...

This week saw the culmination of an international effort to devise guidelines to strengthen and standardise the reporting of genetic risk prediction studies. Following a multidisciplinary two-day workshop in December 2009 sponsored by the Human Genome Epidemiology Network, experts came up with a 25-point checklist to be adhered to when reporting the results of genetic risk prediction studies.

The recommendations of the Genetic Risk Prediction Studies (GRIPS) statement aim to 'maximise the transparency, quality and completeness of reporting on research methodology and findings in a particular study' and should ease the pooling of evidence on genetic risk prediction from future studies.

The authors say the guidelines are important due to the success of recent studies in discovering genetic variants that influence the risk of complex diseases, which has led many researchers to study the value of these genetic variants for predicting the risk of disease. These risk models could eventually be useful for improving the clinical management of patients by predicting a individual's response to treatment, prognosis or 'treatment-related harms' based on genetic, and possibly non-genetic, risk factors.

However, the reporting of these studies has been of varying quality and completeness and the authors stress that: 'It is crucial to enhance the quality of the reporting of these studies since valid interpretation could be compromised by the lack of reporting of key information'. The authors add that: 'Proper documentation of genetic predictive research according to GRIPS might facilitate the translation of research findings into clinical and public health practice'.

The GRIPS statement recommendations were published in PLoS Medicine accompanied by a more detailed 'explanation and elaboration' document.

Related Articles

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Reviews
5 February 2013 • 4 minutes read

Book Review: Human Genes and Neoliberal Governance - A Foucauldian Critique

by Dr Stevie de Saille

Arising from Dr Antoinette Rouvroy's doctoral research, Human Genes and Neoliberal Governance was originally published as a hardback in 2008, but has only recently become available in a paperback edition affordable to the general reader. In between those two dates much has happened in the field of genetics and governance, both globally and in the UK...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Comment
29 November 2012 • 3 minutes read

Safeguarding consent and confidentiality in clinical genetic practice

by Professor Anneke Lucassen and 1 others

Suppose you have just had a genetic test for a condition that you suspect runs in your family. Aside from the possible implications for your own health, could — or should — your results be used to help to interpret tests done on other members of your family?...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
News
22 November 2012 • 2 minutes read

Best practice guidelines encourage genetic information sharing

by Julianna Photopoulos

A new report published by the Royal College of Physicians, Royal College of Pathologists and British Society for Human Genetics has encouraged the sharing of genetic information between family members and healthcare professionals as part of good clinical practice....

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
News
20 May 2011 • 2 minutes read

How long will you live? Nobel winner claims new test can help

by Mehmet Fidanboylu

Scientists claim they have developed a blood test that can predict how fast a person is ageing. The test, developed in Spain, is set to be available in the UK soon....

Leave a Reply Cancel reply

You must be logged in to post a comment.

« Egg cells send out chemical signals to entice sperm, suggests study

Data-Label The UK's Leading Supplier Of Medical Labels & Asset Labels

RetiringDentist.co.uk The UK's Leading M&A Company.

Find out how you can advertise here
easyfundraising
amazon

This month in BioNews

  • Popular
  • Recent
8 August 2022 • 2 minutes read

Placenta and organ formation observed in mouse embryo models

8 August 2022 • 2 minutes read

Lower hormone doses may improve IVF egg quality

8 August 2022 • 2 minutes read

Boosting muscle cell production of gene therapy proteins

1 August 2022 • 2 minutes read

First UK medical guidelines issued for trans fertility preservation

1 August 2022 • 2 minutes read

Male age has more impact on IVF birth rate than previously thought

15 August 2022 • 2 minutes read

Call to end ban on HIV-positive partner gamete 'donation'

15 August 2022 • 2 minutes read

Melanoma invades new tissues using nerve cell gene

15 August 2022 • 2 minutes read

Exceeding alcohol limits could damage DNA and accelerate ageing

15 August 2022 • 2 minutes read

Blood cell gene mutations affect mitochondria, increasing cardiovascular disease risk

15 August 2022 • 2 minutes read

Jumping gene helps immune system fight viruses

Subscribe to BioNews and other PET updates for free.

Subscribe
  • Twitter
  • Facebook
  • Instagram
  • LinkedIn
  • YouTube
  • RSS
Wellcome
Website redevelopment supported by Wellcome.

Website by Impact Media Impact Media

  • Privacy Statement
  • Advertising Policy
  • Thanks and Acknowledgements

© 1992 - 2022 Progress Educational Trust. All rights reserved.

Limited company registered in England and Wales no 07405980 • Registered charity no 1139856

Subscribe to BioNews and other PET updates for free.

Subscribe
PET PET

PET is an independent charity that improves choices for people affected by infertility and genetic conditions.

  • Twitter
  • Facebook
  • Instagram
  • LinkedIn
  • YouTube
  • RSS
Wellcome
Website redevelopment supported by Wellcome.

Navigation

  • About Us
  • Get Involved
  • Donate
  • BioNews
  • Events
  • Engagement
  • Jobs & Opportunities
  • Contact Us

BioNews

  • News
  • Comment
  • Reviews
  • Elsewhere
  • Topics
  • Glossary
  • Newsletters

Other

  • My Account
  • Subscribe

Website by Impact Media Impact Media

  • Privacy Statement
  • Advertising Policy
  • Thanks and Acknowledgements

© 1992 - 2022 Progress Educational Trust. All rights reserved.

Limited company registered in England and Wales no 07405980 • Registered charity no 1139856