PET PET
  • My Account
  • Subscribe
Become a Friend Donate
  • About Us
    • People
    • Press Office
    • Our History
  • Get Involved
    • Become a Friend of PET
    • Volunteer
    • Campaigns
    • Writing Scheme
    • Partnership and Sponsorship
    • Advertise with Us
  • Donate
    • Become a Friend of PET
  • BioNews
    • News
    • Comment
    • Reviews
    • Elsewhere
    • Topics
    • Glossary
    • Newsletters
  • Events
    • Upcoming Events
    • Previous Events
  • Engagement
    • Policy and Projects
      • Resources
    • Education
  • Jobs & Opportunities
  • Contact Us
  • About Us
    • People
    • Press Office
    • Our History
  • Get Involved
    • Become a Friend of PET
    • Volunteer
    • Campaigns
    • Writing Scheme
    • Partnership and Sponsorship
    • Advertise with Us
  • Donate
    • Become a Friend of PET
  • BioNews
    • News
    • Comment
    • Reviews
    • Elsewhere
    • Topics
    • Glossary
    • Newsletters
  • Events
    • Upcoming Events
    • Previous Events
  • Engagement
    • Policy and Projects
      • Resources
    • Education
  • Jobs & Opportunities
  • Contact Us
  • My Account
  • Subscribe
  • Privacy Statement
  • Advertising Policy
  • Thanks and Acknowledgements
PETBioNewsNewsUnder right conditions, IVF approaches birth rates of natural conception

BioNews

Under right conditions, IVF approaches birth rates of natural conception

Published 13 March 2013 posted in News and appears in BioNews 663

Author

Dr Sarah West

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.

For the first time, researchers in the USA have calculated cumulative success rates of infertility treatments that use IVF or assisted reproductive technologies (ART), and have showed that overall success rates come close to that of natural conception....

For
the first time, researchers in the USA have calculated cumulative success rates
of infertility treatments that use IVF or assisted reproductive technologies
(ART), and have showed that overall success rates come close to that of natural
conception.

The
study was led by Barbara Luke, professor of obstetrics, gynaecology and
reproductive biology at Michigan State University, and was published in the New
England Journal of Medicine.

The
results show that the cumulative live birth rate using ART, under optimal conditions,
was 75 percent after three cycles of treatment. However, this rate increased to
81 percent when transferring blastocyst embryos (transferred on day five or
six) compared to 65 percent for cleavage embryos (transferred on day two or
three). The estimated rates of conceiving naturally are 45 percent, 65 percent
and 85 percent after three, six and 12 months, respectively.

Until
now, success rates have been reported on a per cycle basis - currently about 30
percent - which does not give patients information on their chance of a live
birth after multiple cycles. However, as Professor Luke points out, 'women and
families want to know the overall chances they will get pregnant, not
necessarily whether they will get pregnant during a specific cycle'.

Around
25 percent of patients cease treatment after the first cycle owing to reasons
including stress and cost, with insurers in the USA only covering two or three
cycles of treatment. The knowledge of overall success rates could help patients
in their decision to continue with treatment and guide health insurance
regulations.

The
study highlighted the decrease in live-birth rates as maternal age increases.
By the third cycle, women of 31 or younger had 75 percent live birth rates
compared to 28 percent for those aged 41 to 42 and 11 percent for those aged over
43.

Dr
Luke said: 'As we age, our eggs age, and the quality of the embryo may be less.
That's why using a donor egg, from a younger women, greatly improves the live birth
rate among older women'. Indeed, the authors found that live birth rate was independent of age when using donor eggs.

Live
birth rates were also found to be highest when two embryos were implanted (77
percent) compared to one or three. Although the authors note that this would
increase the chance of multiple births and associated risks this could incur.

The
lowest rates of live births were among those women whose infertility was caused
by uterine factors or diminished reserve of oocytes, showing that uterine
environment was still an important factor.

The
study was based on data from the Society for Assisted Reproductive Technology (SART)
Clinic Outcome Reporting System database for 246,740 American women who were
treated with ART between 2004 and 2009. The large size of this study allowed
the researchers to compare the effects of the number of embryos transferred,
the day of transfer and the use of previously frozen eggs.

Dr
Glen Schattman, president of SART and a co-author of the study, said the
results provide patients with 'important and encouraging information'. He added:
'While tracking outcomes by cycle started or single embryo transfer is a
valuable method for assessing quality, having cumulative data linked to
individual patients better estimates the prospect for success when they start a
treatment cycle'.

Related Articles

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
21 February 2014 • 2 minutes read

IVF births hit record high in USA

by Chee Hoe Low

More than 61,000 babies born in the USA in 2012 were conceived via IVF - hitting a record high, a report shows...

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
5 September 2013 • 1 minute read

Diminishing returns after five cycles, says Australian IVF study

by Sarah Pritchard

The cumulative chances of a woman getting pregnant following IVF increase with each treatment cycle until the sixth cycle, after which the increases are minimal, show study results from Australia and New Zealand....

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
10 May 2013 • 2 minutes read

IVF single embryo transfer performs well in birth rate study

by Dr Katie Howe

The transfer of one pre-screened embryo during IVF leads to birth rates equivalent to transferring two unscreened embryos, indicates new research from the USA....

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
3 April 2013 • 2 minutes read

Study sparks debate: should embryo cryopreservation be routine in IVF?

by Dr Gabby Samuel

Women who undergo fertility treatment using cryopreserved embryos may have healthier babies and fewer complications than those who use 'fresh' embryos, a study suggests....

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
13 March 2013 • 2 minutes read

IVF single embryo transfers have better chance of survival

by Dr Gabby Samuel

Single embryo transfer reduces the risk of death within a month of birth for babies conceived via IVF, according to an Australian study...

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
21 February 2013 • 1 minute read

IVF can't beat biological clock, warns Yale fertility expert

by Cathy Holding

A leading fertility expert in the USA has warned of young women's have serious misconceptions about their own fertility...

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
31 January 2013 • 2 minutes read

IVF chances boosted by 10 percent using new procedure

by Dr Linda Wijlaars

Protecting embryos from a laboratory environment during IVF treatment could increase successful pregnancy rates from 35 percent to 45 percent. A novel system, trialled in a recent study, consists of a chain of fully enclosed, interlinked incubators, provides a tightly controlled and protected environment...

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
30 January 2013 • 1 minute read

Chromosome analysis increases IVF success

by Ayesha Jadoon

A new method of looking for chromosomal abnormalities in embryos can increase the chance of successful IVF implantation, a recent study in the journal Fertilisation In Vitro has shown....

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
12 November 2012 • 1 minute read

Experts say '15' may not be the perfect number for IVF success after all

by Dr Rosie Morley

A US fertility clinic has issued a press release warning against simplistic interpretations of a recent report on IVF success rates...

Leave a Reply Cancel reply

You must be logged in to post a comment.

« Gene test may reduce unnecessary thyroid surgeries

Data-Label The UK's Leading Supplier Of Medical Labels & Asset Labels

RetiringDentist.co.uk The UK's Leading M&A Company.

Find out how you can advertise here
easyfundraising
amazon

This month in BioNews

  • Popular
  • Recent
8 August 2022 • 2 minutes read

Placenta and organ formation observed in mouse embryo models

8 August 2022 • 2 minutes read

Lower hormone doses may improve IVF egg quality

8 August 2022 • 2 minutes read

Boosting muscle cell production of gene therapy proteins

1 August 2022 • 2 minutes read

First UK medical guidelines issued for trans fertility preservation

1 August 2022 • 2 minutes read

Male age has more impact on IVF birth rate than previously thought

15 August 2022 • 2 minutes read

Call to end ban on HIV-positive partner gamete 'donation'

15 August 2022 • 2 minutes read

Melanoma invades new tissues using nerve cell gene

15 August 2022 • 2 minutes read

Exceeding alcohol limits could damage DNA and accelerate ageing

15 August 2022 • 2 minutes read

Blood cell gene mutations affect mitochondria, increasing cardiovascular disease risk

15 August 2022 • 2 minutes read

Jumping gene helps immune system fight viruses

Subscribe to BioNews and other PET updates for free.

Subscribe
  • Twitter
  • Facebook
  • Instagram
  • LinkedIn
  • YouTube
  • RSS
Wellcome
Website redevelopment supported by Wellcome.

Website by Impact Media Impact Media

  • Privacy Statement
  • Advertising Policy
  • Thanks and Acknowledgements

© 1992 - 2022 Progress Educational Trust. All rights reserved.

Limited company registered in England and Wales no 07405980 • Registered charity no 1139856

Subscribe to BioNews and other PET updates for free.

Subscribe
PET PET

PET is an independent charity that improves choices for people affected by infertility and genetic conditions.

  • Twitter
  • Facebook
  • Instagram
  • LinkedIn
  • YouTube
  • RSS
Wellcome
Website redevelopment supported by Wellcome.

Navigation

  • About Us
  • Get Involved
  • Donate
  • BioNews
  • Events
  • Engagement
  • Jobs & Opportunities
  • Contact Us

BioNews

  • News
  • Comment
  • Reviews
  • Elsewhere
  • Topics
  • Glossary
  • Newsletters

Other

  • My Account
  • Subscribe

Website by Impact Media Impact Media

  • Privacy Statement
  • Advertising Policy
  • Thanks and Acknowledgements

© 1992 - 2022 Progress Educational Trust. All rights reserved.

Limited company registered in England and Wales no 07405980 • Registered charity no 1139856