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PETBioNewsNewsMonkey born following ovary transplant

BioNews

Monkey born following ovary transplant

Published 9 June 2009 posted in News and appears in BioNews 229

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BioNews

Image by Alan Handyside via the Wellcome Collection. Depicts equipment used for embryo biopsy.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts equipment used for embryo biopsy.

US scientists have carried out the world's first successful ovary tissue transplant in a primate, and have used one of the resulting eggs to produce a healthy IVF baby monkey. Team leader David Lee, of Oregon University, said it was the first time transplanted ovarian tissue had been used to...

US scientists have carried out the world's first successful ovary tissue transplant in a primate, and have used one of the resulting (1680, eggs)} to produce a healthy IVF baby monkey. Team leader David Lee, of Oregon University, said it was the first time transplanted ovarian tissue had been used to create a healthy infant. He said that the procedure could be used to preserve the fertility of cancer survivors, to treat early menopause, and also 'suggests that ovarian tissue banking in humans may be feasible'. He presented the results at the annual American Society for Reproductive Medicine, being held in San Antonio, Texas this week.


To carry out the procedure, the researchers removed the ovaries from seven rhesus macaque monkeys, and re-implanted slices of tissue into either the kidney, arm or the abdomen. All the monkeys then began producing female hormones, and four also produced eggs, of which two were fertilised using ICSI (intracytoplasmic sperm injection). These embryos were returned to the womb of a surrogate mother, and a healthy female infant was born last year. Although scientists have already successfully carried out ovarian transplants resulting in live births in rats and sheep, this is apparently the first time the procedure has worked in a primate. 'This experiment brings us a little closer to doing it in humans' said ovarian transplant expert Roger Gosden.


Ovary-tissue banking could help female cancer patients who have to undergo radiotherapy, chemotherapy or ovary removal: treatment that can leave them infertile. Ovarian tissue survives freezing and thawing much more readily than eggs, and some women are already freezing such tissue before cancer treatment, in the hope that they can use it in the future. But so far, the technique has not yet succeeded in human trials.


Despite UK media speculation following reports of the US team's success, many scientists are sceptical that the procedure could one day be used by healthy women to store ovarian tissue, to allow them to have a baby in their late 40s or 50s. 'We're a long way from that' Oregon researcher Nancy Klein told the BBC. 'There's a great loss rate of the number of eggs that will survive the freezing process, and so it requires usually the removal of a whole ovary. Women who are already in their mid-30s probably won't have enough eggs to make that a feasible approach' she said.

Related Articles

Image by Alan Handyside via the Wellcome Collection. Depicts equipment used for embryo biopsy.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts equipment used for embryo biopsy.
Comment
18 June 2009 • 2 minutes read

Ovarian transplant success is cause for celebration

by Dr Jess Buxton

This week, BioNews reports on the world's first baby born following a transplant of frozen, thawed ovary tissue. This is the first success for a technique that promises to benefit thousands of women who would otherwise lose their fertility forever. Ouarda Touriat, who underwent lifesaving cancer treatment that left her...

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
9 June 2009 • 1 minute read

Child born following whole ovary transplant

by Adam Fletcher

A 39-year old woman has become the first to give birth following a whole ovary transplant. Susanne Butscher received an intact ovary from her fertile twin sister last year, during a landmark operation carried out by Dr Sherman Silber of the Infertility Centre of St Louis...

Image by Alan Handyside via the Wellcome Collection. Depicts equipment used for embryo biopsy.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts equipment used for embryo biopsy.
News
9 June 2009 • 2 minutes read

Frozen-thawed ovary transplant success in sheep

by BioNews

Israeli scientists have obtained early sheep embryos after transplanting whole ovaries that had been frozen and thawed. The researchers, based at the Institute of Animal Science, Agriculture Research Organisation, Bet Dagan, report that the ovaries were still working normally three years after the transplant. They say their findings, published in...

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
9 June 2009 • 2 minutes read

First frozen ovary tissue birth

by BioNews

The first woman in the world to become pregnant following a transplant of her own frozen, thawed ovarian tissue has given birth to a healthy baby girl. In 1997, Ouarda Touirat, now aged 32, had parts of her ovaries removed before beginning treatment for Hodgkin's lymphoma that would leave her...

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
9 June 2009 • 2 minutes read

Success in ovarian tissue grafting

by BioNews

BioNews reporting from the ESHRE conference, Berlin: Danish researchers have reported that they are on the verge of producing a pregnancy from frozen-thawed human ovarian tissue, while in Belgium it transpires that a woman is already 25 weeks pregnant following similar treatment - the first time this treatment has ever led...

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