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PETBioNewsNewsCloning humans may be easier than you think

BioNews

Cloning humans may be easier than you think

Published 20 August 2001 posted in News and appears in BioNews 121

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BioNews

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.

Scientists from the US Duke University Medical Centre in Durham, North Carolina, have discovered that it may be easier to clone a human than it is to clone sheep, mice or other mammals. It is thought that this is because humans possess a single genetic difference that has not been...

Scientists from the US Duke University Medical Centre in Durham, North Carolina, have discovered that it may be easier to clone a human than it is to clone sheep, mice or other mammals. It is thought that this is because humans possess a single genetic difference that has not been present in other animals, the lack of which has proved an obstacle to the success of animal cloning.


The researchers, who published their findings in the journal Human Molecular Genetics, say that humans and other primates each have two working copies of a gene called insulin-like growth factor II receptor (IGF2R). One copy of the gene is passed from each parent to its offspring. It is thought that other mammals, such as sheep, pigs, cows and mice, only ever receive one functioning copy of the gene because of a process called genomic imprinting.


Having two functioning copies of the IGF2R gene is thought to help prevent fetal enlargement and susceptibility to cancer and other disorders common to cloned mammalian offspring. Keith Killian, leader of the research team, said 'this is the first concrete data showing that the cloning process could be less complicated in humans than in sheep'.

Sources and References

  • 15/08/2001
    BBC News Online
    Cloning humans 'easier' than animals
  • 15/08/2001
    The Independent
    Humans 'easier to clone than sheep or mice'
  • 15/08/2001
    ScienceDaily
    Humans may be easier to clone than sheep and mice because of a single genetic difference

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