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PETBioNewsGlossaryGenetic modification/engineering

BioNews

Genetic modification/engineering

The alteration of an organism's or a cell's genetic material using biotechnology techniques. Traditionally, the term has referred only to alterations involving the introduction of transgenic (foreign) DNA.

397 articles
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family (from Greek and Roman mythology) entwined in coils of DNA.
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family entwined in coils of DNA (based on the figure of Laocoön from Greek and Roman mythology).
Comment
7 February 2022 • 4 minutes read

Pigs: a new breed of organ donors

by Dr Anna Smajdor

In January 2022, a heart transplant patient named David Bennett became world famous when it was reported that the 'donor' of the heart that had saved his life was – a pig...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
News
4 February 2022 • 2 minutes read

Leukaemia patients still in remission a decade after CAR-T gene therapy

by Farah Alam

Two patients who received CAR-T gene therapy over a decade ago are still in remission, the longest follow-up study of its kind has shown...

PET BioNews
Reviews
23 August 2021 • 4 minutes read

Radio Review: Genetic Dreams, Genetic Nightmares

by Anna Wernick

Hosted by Professor Matthew Cobb of the University of Manchester, Genetic Dreams, Genetic Nightmares took me back to his lectures during my undergraduate degree there...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Comment
12 July 2021 • 5 minutes read

Should we edit human embryos' genomes, and if so then how?

by Dr Dieter Egli

I recently received a thoughtful letter from a college student I do not know – I'll call her Claudia* – who took the time to reach out to me with her perspective on heritable genome editing in embryos...

PET BioNews
Reviews
21 October 2019 • 4 minutes read

TV Review: Eugenics: Science's Greatest Scandal

by Dr Marieke Bigg

In the BBC documentary, Eugenics: Science's Greatest Scandal, science journalist Angela Saini and disability rights activist Adam Pearson tackle the difficult subject of eugenics...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Comment
9 July 2018 • 5 minutes read

Australia's careful step towards legalising mitochondrial donation

by Professor Ainsley Newson

Mitochondrial donation has seeded a growing literature in bioethics, law and the social sciences. This technology, which introduces third-party mitochondria to an embryo or oocyte, has contributed to many long-standing social and ethical questions...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Reviews
25 June 2018 • 5 minutes read

Book Review: Genetics

by Mikey Lebrett

Nostalgia is a powerful driver of human behaviour. Over the past three years, Penguin Random House has tapped into this emotion by launching adult books with the unmistakable writing style, illustrations and appearance of the classic Ladybird children's b

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
News
8 June 2018 • 2 minutes read

FDA puts major CRISPR genome editing trial on hold

by Christie Whitehouse

The US drugs regulator has put on hold an application for a clinical trial of a new genome editing based treatment for sickle cell disease...

Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
CC BY 4.0
Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
News
27 February 2018 • 2 minutes read

Sheep embryos with human cells grown for first time

by Kathryn Ashe

Scientists have successfully grown sheep embryos containing human cells, taking a step towards a method for growing human organs in animals for transplantation...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
News
26 February 2018 • 2 minutes read

Gene therapy effective for treatment-resistant leukaemia

by Dr Sam Sherratt

A new gene therapy for leukaemia is effective for a majority of patients who showed resistance to previous therapies...

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4 July 2022 • 4 minutes read

Widening the debate about direct-to-consumer genetic testing and donor conception

4 July 2022 • 3 minutes read

Join PET and Genomics England to celebrate the 200th birthday of Gregor Mendel

27 June 2022 • 4 minutes read

Thirty years of PET: our 'Fertility, Genomics and Embryo Research' report

27 June 2022 • 5 minutes read

Children's rights and donor conception: What next?

20 June 2022 • 4 minutes read

The problems with lifting donor anonymity earlier

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