Scientists at Mammoth Biosciences in California, a company co-founded by Professor Jennifer Doudna of the University of California, Berkeley, have reported the development of an ultracompact CRISPR genome editing system, called NanoCas.
Along with Professor Emmanuelle Charpentier, Professor Doudna was awarded the 2020 Nobel Prize in Chemistry 'for the development of a method of genome editing' known as CRISPR (see BioNews 1067).
Publishing their findings as a preprint in bioRxiv that has not yet been peer-reviewed, the scientists have successfully used NanoCas in mice and monkeys to edit a gene linked to neuromuscular disorders.
The scientists propose that NanoCas can be used in reverse transcriptase editing, base editing and epigenetic editing.
Read Genetic Engineering and Biotechnology News for more information.