Making deliberate alterations to the DNA sequence at targeted locations in the genome. This can include deleting, inserting or replacing sections of DNA. Several approaches can be used to achieve these changes including zinc finger nucleases (ZFNs), TALENs, CRISPR/Cas and base editing.
A new genome editing method allows long DNA fragments to be integrated into precise positions within the genome of cells...
Base editing can efficiently alter the DNA of human embryos, but it can also result in unintended genomic changes....
A genetically modified pig kidney has functioned inside a living patient for a record nine months, successfully serving as a temporary bridge to a subsequent human donor transplant for the first time...
A CRISPR-based therapy continues to reduce harmful cholesterol levels in patients after a one-year follow-up in a Phase 1 clinical trial...
Dr Tom Turner explores Professor Jennifer Doudna's reflections on the discovery of CRISPR and the future of genome editing in this conversation, which examines one of the most transformative advances in modern biology…
A six-year-old girl has died following an experimental genome editing treatment, prompting an investigation into the clinical trial by the university involved...
Behind every scientific breakthrough is a story. Dr Oliver Bower, the lead author of a recent Nature study, describes how listening to people affected by genetic disease reshaped his research and his perspective on the future of genome editing...
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