Making deliberate alterations to the DNA sequence at targeted locations in the genome. This can include deleting, inserting or replacing sections of DNA. Several approaches can be used to achieve these changes including zinc finger nucleases (ZFNs), TALENs, CRISPR/Cas and base editing.
A six-year-old girl has died following an experimental genome editing treatment, prompting an investigation into the clinical trial by the university involved...
Behind every scientific breakthrough is a story. Dr Oliver Bower, the lead author of a recent Nature study, describes how listening to people affected by genetic disease reshaped his research and his perspective on the future of genome editing...
A landmark study highlights the importance of donated embryos and gametes in reproductive research. Dr Valerie Shaikly argues that more patients should have the opportunity to donate...
The PET team discusses findings from a PET/ESHRE report exploring attitudes to fertility treatment, embryo research, genome editing, donor conception, surrogacy and related topics in the UK, the Netherlands, Spain and Italy...
Using base editing, a highly precise method of genome editing, scientists have investigated the role of the NANOG gene in human embryos for the first time with this approach...
Former consultant embryologist Jane Blower was recognised in this year's King's Birthday Honours List alongside Professors Andrew Mumford, Bruce Whitelaw and Gareth Evans...
The US Food and Drug Administration has proposed allowing manufacturers of cell and gene therapies to make use of existing scientific and platform knowledge during product development...
A CRISPR genome editing therapy provides sustained reductions in 'bad' cholesterol in people with inherited high cholesterol or premature coronary artery disease, an early-stage clinical trial shows...
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