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PETBioNewsNews'Sleeping Beauty' pancreatic stem cells woken in fight against diabetes

BioNews

'Sleeping Beauty' pancreatic stem cells woken in fight against diabetes

Published 9 June 2009 posted in News and appears in BioNews 442

Author

Dr Karen Devine

Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour).
CC BY 4.0
Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false-coloured cryogenic scanning electron micrograph).

Researchers this week have reported that the much debated and 'elusive' insulin-producing stem cells really do exist in the pancreas. Despite scepticism over their actual existence, stem cells that can produce beta cells were found within the pancreas of adult mice during a study at the Diabetes...

Researchers this week have reported that the much debated and 'elusive' insulin-producing stem cells really do exist in the pancreas. Despite scepticism over their actual existence, stem cells that can produce beta cells were found within the pancreas of adult mice during a study at the Diabetes Research Centre at the Vrije University, Brussels and the results of the study published in the journal Cell.


Researchers found that if they damaged the pancreas in a certain way, the mice produced stem cells that could generate the beta cells. By preventing enzymes from draining away from this vital organ, an inflammatory response induced the cells to produce more insulin and spark a regenerative process. Senior researcher at the Centre, Harry Heimberg, said 'they were quite hard to find. I sometimes call them sleeping beauties as they are hard to wake up'. But wake them up they did - and as a result, their efforts may have enormous consequences for people with type 1 diabetes. The disease, which most commonly affects young people, develops when, for unknown reasons, the body's own immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. Affected patients have to inject themselves daily with insulin to maintain normal glucose levels in their blood.


Pancreatic beta cells can be procured from cadavers and have been used successfully in pancreatic cell transplants, but the cells are difficult to isolate, are fragile and several donors are needed for one transplant. Furthermore, attempts to programme embryonic stem cells (ES cells) into beta cells have so far proved unsuccessful. Consequently, the discovery of an alternative source of beta cells has excited the medical world. Emmanuel Baetege, chief scientific officer of Novocell, a Californian-based stem cell company, is reported by Nature as proclaiming 'It's a big discovery - I think this will heat up the whole field'. In addition, the Washington Post reports that Juan Dominquez-Bendala, director of Stem Cell Development for Translational Research at the Diabetes Research Institute of the University Miami Miller School of Medicine, said 'from a basic point of view, it's very exciting. It opens the door to potential therapies. If we could trigger regeneration, that would be fantastic'. Indeed, Heimberg is quoted in the same press report as saying, 'If this kind of cell and their progenitors with a capacity to divide exist in the pancreas of man, and if we can identify the factors that are responsible to induce their proliferation and differentiation, then these latter processes might be stimulated in vitro but also, by non-invasive means, in vivo'.


Whilst the discovery of insulin-producing cells is undoubtedly an incredible break-through in stem cell science, Heimberg also urges caution and has reiterated that any potential treatment remains far in the future.

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Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
CC BY 4.0
Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
News
9 June 2009 • 2 minutes read

Stem cell hope for type 1 diabetes

by Ailsa Stevens

The US Geron Corporation has reported pioneering steps towards a new treatment for type 1 diabetes, having successfully converted human embryonic stem (ES)cells into insulin-producing cells. The research, published in the journal Stem Cells, found that islet-like clusters of cells, similar to those normally found in...

Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour).
CC BY 4.0
Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false-coloured cryogenic scanning electron micrograph).
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9 June 2009 • 1 minute read

Stem cell research news

by BioNews

Canadian scientists report that they have identified insulin-producing stem cells in the adult mouse pancreas, a finding they say offers hope for people with diabetes. Team leader Simon Smukler called the discovery 'very exciting', since scientists have been searching for pancreatic stem cells for some time. The researchers, based at...

Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour).
CC BY 4.0
Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false-coloured cryogenic scanning electron micrograph).
News
9 June 2009 • 2 minutes read

Doubt cast on adult stem cell therapies

by BioNews

A new US study calls into question the existence of adult stem cells capable of transforming into insulin-producing pancreatic cells. Previous research in mice has suggested that such cells could be used to develop new treatments for diabetes. But the new study, carried out by scientists at Harvard University in...

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