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PETBioNewsNewsStudy shows that 'identical twins' are not genetically identical

BioNews

Study shows that 'identical twins' are not genetically identical

Published 23 October 2012 posted in News and appears in BioNews 602

Author

Dr Jay Stone

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.

Scientists from the University of Western Ontario have found that identical twins may not be as identical as we first thought....

Scientists from the University of Western Ontario have found that identical twins may not be as identical as first thought.

Identical twins are formed when a single egg is fertilised and then splits during development. The children inherit the same gene set from their parents and for over a century have been widely thought to be genetic copies of one another.

Schizophrenia is considered to have a genetic component with your chances of developing it greatly increased if a parent or sibling suffers from it. However, it has been documented that in an identical twin scenario if one twin develops schizophrenia it does not mean the other will. This suggests the disease is not purely genetic or that the identical twins might not have the same genes as each other after all.

Molecular geneticist Dr Shiva Singh of the University of Western Ontario's Faculty of Science, compared one million markers of identical twins and their parents, in which one twin had schizophrenia. Dr Singh identified key differences in the twins' genetics and found that 12 percent of DNA could vary across individuals.

He said in a statement: 'Cells are dividing as we develop and differentiate. More importantly, these cells may lose or acquire additional DNA. The genome is not static. Our results have really forced everyone to rethink the idea that identical twins are actually identical. The implication would be that there is nobody with the [same] human genome sequence, everybody is different'.

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