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PETBioNewsGlossarycfDNA

BioNews

cfDNA

cfDNA (circulating DNA or cell-free DNA) are fragments of DNA that are released into the blood.

Elevated levels are seen in cancer and they can be detected using 'liquid biopsies' to aid diagnosis. Fetal cfDNA can be detected in maternal blood through non-invasive prenatal testing.

10 articles
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
News
22 April 2022 • 2 minutes read

FDA recommends additional confirmatory testing alongside NIPT

by Jessica Peixinho

Prenatal genetic test results need to be communicated better, according to the US Food and Drug Administration...

Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family (from Greek and Roman mythology) entwined in coils of DNA.
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family entwined in coils of DNA (based on the figure of Laocoön from Greek and Roman mythology).
News
10 September 2021 • 2 minutes read

NIFTY non-invasive prenatal test scrutinised over links to Chinese military

by Christina Burke

Health regulators in five countries are investigating non-invasive prenatal test NIFTY, over data protection concerns....

Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1997. Depicts the gyri of the Thinker's brain as a maze of choices in biomedical ethics (based on Auguste Rodin's 'The Thinker').
CC BY 4.0
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1997. Depicts the gyri of the Thinker's brain as a maze of choices in biomedical ethics (based on the sculpture 'The Thinker' by Auguste Rodin).
News
23 July 2021 • 2 minutes read

NIPT may be less effective in twin pregnancies

by Tsvetana Stoilova

Non-invasive prenatal testing to detect chromosomal abnormalities in twin pregnancies is not as accurate as in singleton pregnancies...

Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family (from Greek and Roman mythology) entwined in coils of DNA.
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family entwined in coils of DNA (based on the figure of Laocoön from Greek and Roman mythology).
News
28 May 2021 • 2 minutes read

Illumina and Roche settle and dismiss patent lawsuits over 'Harmony' tests

A long-running court case over non-invasive prenatal testing patents has been settled...

PET BioNews
News
16 November 2018 • 2 minutes read

Epigenetic approach could detect cancer early

by Eleanor Mackle and 1 others

Canadian researchers have published two new studies using machine learning to improve detection and treatment of cancer...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
News
5 October 2018 • 2 minutes read

Prenatal tests provide largest genetic study of Chinese people

by Dr Sam Sherratt

The largest genetic analysis of China's population to date has been carried out on over 140,000 pregnant women, revealing new insights into migration patterns and disease risk in Chinese people...

Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1997. Depicts the gyri of the Thinker's brain as a maze of choices in biomedical ethics (based on Auguste Rodin's 'The Thinker').
CC BY 4.0
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1997. Depicts the gyri of the Thinker's brain as a maze of choices in biomedical ethics (based on the sculpture 'The Thinker' by Auguste Rodin).
News
5 July 2018 • 2 minutes read

DNA shed by embryos could offer non-invasive testing

by Shaoni Bhattacharya

DNA shed from early embryos could one day provide an alternative way of genetically testing them without having to do a biopsy, suggests a small pilot study...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
News
1 June 2018 • 2 minutes read

Liquid biopsy test offers hope for ten cancers

by Shaoni Bhattacharya

A new blood test which can detect ten cancers at an early stage is offering hope as a way to screen for multiple cancers...

Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family (from Greek and Roman mythology) entwined in coils of DNA.
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family entwined in coils of DNA (based on the figure of Laocoön from Greek and Roman mythology).
News
5 December 2017 • 2 minutes read

Illumina wins NIPT patent case in UK High Court

by Dr Rachel Montgomery

The UK Patents Court has ruled that two separate non-invasive prenatal tests infringe patents licensed by the US firm Illumina...

PET BioNews
News
24 August 2017 • 2 minutes read

Liquid DNA biopsies could be used for cancer screening

by Dr Loredana Guglielmi

US researchers have developed a new blood test to detect cancer-related DNA alterations before patients experience symptoms...

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