Involving, or controlled by a single gene. Monogenetic conditions include Huntington's disease and cystic fibrosis.
Dr Emma Meaburn explains what polygenic scores are, and what they can and cannot tell us about a person's risk of – or resilience to – a complex trait...
Genomics has the potential to reshape the NHS into a more proactive, cost-efficient, and patient-responsive system, writes Zeenat Beebeejaun. But it can only do so if built on a foundation of trust, transparency, and fairness...
The British health insurance and healthcare company Bupa plans to offer an approach to people's genomic data that, it is claimed, can evaluate an individual's risk of developing seven common diseases...
Common genetic variants, including some linked to risk of developing schizophrenia and depression in later life, are linked to the risk of rare neurodevelopmental conditions in children...
Eight percent of UK adults have the same risk of heart disease due to cumulative polygenic changes as carriers of a single rare mutation, according to a study...
It is crucial to focus not just on scientific concerns about PGT-P, but also on broader potential consequences for those who could be impacted by the technology, explains Maria Siermann...
A timely conversation focused on the bioethical concerns wrapped up in the clinical use of polygenic embryo screening...
A type of genome editing capable of replacing entire genes in the human genome could potentially be used to treat a wide variety of genetic conditions...
Screening gamete donors could reduce transmission of recessive genetic conditions, but also gives rise to new and ethically sensitive questions for recipients, clinicians and donors...
Academics from Oxford University discuss the ethics surrounding preimplantation genetic screening tests, including the use of polygenic risk scores...
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