Unintended changes to a genome, away from the desired target site, which occur as a consequence of genome editing.
Full-term mouse offspring were derived from single unfertilised eggs using targeted CRISPR/Cas9 epigenome editing...
Two prominent Chinese bioethicists have recommend the jailed scientist, Dr He Jiankui, be made financially, morally and legally responsible for the health and wellbeing of the children he genome-edited...
A new technique to turn therapeutic genes on in specific cells has been developed, potentially changing the future of gene therapies...
In-depth mapping of DNA repair mechanisms of the double-stranded and single-stranded breaks required for genome editing, could enhance the efficacy of these approaches, new research has revealed...
The Centre for Bioethics and Harvard Medical School, Massachusetts, presented a fascinating talk on the opportunities for great medical advancements, and grave harm, presented to researchers by CRISPR/Cas9 and other apporaches to genome editing...
Base editing, a form of genome editing, has been used in preclinical model to correct a lysosomal storage disease known as Hurler syndrome...
Using CRISPR/Cas9 genome editing in human embryos may introduce 'on-target' errors...
A type of genome editing had been used in mice to treat the symptoms of progeria, a fatal premature ageing disease in children...
CRISPR-based genome editing has revolutionised molecular life sciences, however the ISSCR provides guidelines for responsible and ethical research to achieve safe and effective use...
The safety and efficiency of CRISPR genome editing can be improved by identifying the best genome editing option for a specific application...
