Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
BioNews
Off-target effects
Unintended changes to a genome, away from the desired target site, which occur as a consequence of genome editing.
45 articles
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Extra chromosomal DNA in tumours fuels cancer growth
Circular DNA existing outside chromosomes can drive cancer growth and is a potential drug target, according to three papers published this week in Nature...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
First patient receives novel in vivo gene therapy for blood cancer
A novel gene therapy approach that directly targets immune cells within a patient's body has been trialled in a B-cell cancer patient...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Podcast Review: Make People Better
A podcast series to accompany the film 'Make People Better' gives unique insights into the controversial creation of genome-edited babies by Dr He Jiankui...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
'Prime' genome editing inserts whole gene sequences
A type of genome editing capable of replacing entire genes in the human genome could potentially be used to treat a wide variety of genetic conditions...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Ethics of germline genome editing to prevent genetic diseases from an Islamic perspective
Dr Sayyed Mohamed Muhsin and Dr Alexis Heng Boon Chin give an ethical analysis of germline genome editing to prevent genetic diseases based on Islamic legal maxims (Qawaid Fiqhiyyah)...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Harmless off-target proteins produced by COVID-19 RNA vaccine
RNA-based vaccines for COVID-19 can be misread by the body, producing harmless off-target proteins, according to new research...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Research into gene therapy reveals blood cancer risk
A gene therapy treatment for sickle cell disease has led to a build-up of cells with genetic mutations that make them grow faster, increasing blood-cancer risk, researchers revealed...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Unintended consequence of CRISPR/Cas9 genome editing discovered
CRISPR/Cas9 genome editing can result in the unintended deletion of a region associated with cancer...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
First CRISPR therapy evaluated by FDA advisers
A CRISPR-based treatment for sickle cell disease is one step closer to approval after an advisory committee for the US Food and Drug Administration met to review its safety...