Unintended changes to a genome, away from the desired target site, which occur as a consequence of genome editing.
A new genome editing method allows long DNA fragments to be integrated into precise positions within the genome of cells...
Using base editing, a highly precise method of genome editing, scientists have investigated the role of the NANOG gene in human embryos for the first time with this approach...
The physical shape of DNA in a cell influences the rate of unintended, off-target effects of CRISPR/Cas9 genome editing...
A new genome editing approach has been shown to safely and efficiently remove the source of transthyretin amyloidosis in mice, demonstrating greater therapeutic opportunities for genome editing...
CRISPR-based genome editing has been used to overcome chemotherapy resistance in lung tumours by disabling a tumour-specific mutation...
A new multipurpose genome editing approach could address around a third of rare genetic diseases...
A new mRNA-based therapy has restored fertility in mice that were unable to produce sperm...
An artificial intelligence tool for helping to create CRISPR workflows can enable beginners to design successful experiments in a single attempt...
A precision genome editing approach has successfully corrected harmful mutations in mitochondrial DNA, offering new hope for treating currently incurable mitochondrial diseases...
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