Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
BioNews
Off-target effects
Unintended changes to a genome, away from the desired target site, which occur as a consequence of genome editing.
54 articles
Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
Base editing reveals gene essential for human embryo formation
Using base editing, a highly precise method of genome editing, scientists have investigated the role of the NANOG gene in human embryos for the first time with this approach...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
CRISPR off-target effects explained by DNA coiling
The physical shape of DNA in a cell influences the rate of unintended, off-target effects of CRISPR/Cas9 genome editing...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
CRISPR/Cas3 genome editing shows promise in treating protein misfolding disease
A new genome editing approach has been shown to safely and efficiently remove the source of transthyretin amyloidosis in mice, demonstrating greater therapeutic opportunities for genome editing...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Chemotherapy resistance in solid tumours overcome with CRISPR
CRISPR-based genome editing has been used to overcome chemotherapy resistance in lung tumours by disabling a tumour-specific mutation...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
New prime editing approach could potentially treat multiple genetic diseases
A new multipurpose genome editing approach could address around a third of rare genetic diseases...
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
mRNA treatment helps mice with azoospermia to regain fertility
A new mRNA-based therapy has restored fertility in mice that were unable to produce sperm...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Automating genome editing with CRISPR-GPT
An artificial intelligence tool for helping to create CRISPR workflows can enable beginners to design successful experiments in a single attempt...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Base editing corrects mitochondrial DNA mutation in human cells
A precision genome editing approach has successfully corrected harmful mutations in mitochondrial DNA, offering new hope for treating currently incurable mitochondrial diseases...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
