ICSI and ovarian stimulation linked to different patterns in children's DNA
Parental age and various procedures used during assisted reproductive technology have been linked to different patterns of mutational changes in the DNA of offspring...
BioNews
Genetic variant
A relatively common (present in more than 1% of the population) alternative version of a DNA sequence. Some variants are associated with particular traits and disorders, but many have no observable effect on appearance or health.
695 articles
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
The Genetics of Infertility: Causes, Choices and Treatments
Genetic testing is beginning to identify causes of infertility that were previously unexplained. PET's latest event brought together clinicians and researchers to discuss the opportunities and limitations of reproductive genetics...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
AI atlas models the effects of nine billion DNA variants
A new AI-powered database predicts the effects of single-nucleotide changes in any of the three billion bases in human DNA...
Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour).
TV Review: EastEnders – Stem cells in Albert Square
As a lifelong EastEnders viewer and genetics editor at BioNews, Dr Joanne Delange takes a closer look at the science behind Denise Fox's stem cell transplant storyline and the genetics of finding a suitable donor…
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Sperm from donor carrying disease-associated gene variant used to conceive 53 children
Sperm from a Danish donor carrying a genetic variant classified as 'likely pathogenic' was used by 39 women in Belgium to conceive 53 children...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
More than 1200 genetic variants linked to personality traits
Over 1200 genetic variants associated with differences in personality have been identified in the largest study of its kind...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Rare gene variants offer new insights into Alzheimer's disease biology
The role of PLCG2 – a gene linked to Alzheimer's disease – in brain health may be broader than previously thought, a new study suggests...
'Choosing not to look is not the same as not caring' – public attitudes to embryo selection
People's opinions on using preimplantation genetic testing for non-medical traits do not always reflect the decisions they make about selecting embryos when presented with the results...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Gene therapy restores heart function in mice and human heart organoids
Gene therapy designed to deliver a healthy copy of the ALPK3 gene can restore heart function, raising the possibility of a future treatment for some forms of inherited cardiomyopathy...