Making deliberate alterations to the DNA sequence at targeted locations in the genome. This can include deleting, inserting or replacing sections of DNA. Several approaches can be used to achieve these changes including zinc finger nucleases (ZFNs), TALENs, CRISPR/Cas and base editing.
At PET's recent conference, Professor Azim Surani claimed that permission to carry out experiments on embryos beyond the 14-day rule could make a huge difference to research. It may be time to review the ethical reasoning behind this time limit...
A litter of puppies has been born through IVF for the first time, reports a study that has implications not only for veterinary medicine but also for human genetic research...
This 50-minute radio broadcast provides an 'appetiser' on CRISPR and the ethics surrounding genome editing...
An international summit has agreed conditions under which human genome editing, using techniques like CRISPR, should proceed...
Scientists in China have used the gene-editing technique CRISPR/Cas9 to create dogs with increased muscle mass...
Researchers say that the gene-editing technique CRISPR/Cas9 could be used to increase the safety of organ transplantation from pig to human...
The UNESCO International Bioethics Committee has released a statement reaffirming an earlier moratorium called by a group of US scientists on the use of CRISPR/Cas9 in human embryos. We argue that the current framing of the debate in terms of dystopic or imagined futures is too narrow and constrains the boundaries of the debate to germline applications...
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