BioNews
Organoid
An artificially grown mass of cells or tissue that resembles an organ.
132 articles
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family (from Greek and Roman mythology) entwined in coils of DNA.
Embryo research and stem cells in France: What might change?
France will need to update its bioethics law by 2028. Adrien Bottacci explains what recent recommendations could mean for the 14-day limit on human embryo research, and for research involving stem-cell-based embryo models...
Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour).
Cigarette smoke alters lung stem cells, resulting in different cancers
Chronic cigarette smoke exposure may change lung stem cells in ways that influence which types of lung cancer develop when cancer-driving genetic alterations occur...
Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour).
Salivary gland organoids developed from human pluripotent stem cells
Human salivary gland organoids derived from pluripotent stem cells have been transplanted into mice....
Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour).
Human brain tissue grows and connects inside engineered mice
Human organoids transplanted into mouse brains can grow and form connections with the surrounding nervous system...
Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour).
What are the morally relevant features of stem-cell-based embryo models?
Dr Naomi Moris and an international group of colleagues propose three broad categories of ethical value and five categories of morally relevant biological features that can inform oversight of research involving human stem-cell-based embryo models...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Human brain organoids kept for more than five years in a dish
Human brain organoids have been kept in culture for more than five years, extending the period over which these models of human brain development have previously been maintained...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Gene therapy restores heart function in mice and human heart organoids
Gene therapy designed to deliver a healthy copy of the ALPK3 gene can restore heart function, raising the possibility of a future treatment for some forms of inherited cardiomyopathy...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Tumour organoid biobank maps gene dependencies in multiple cancers
A comprehensive biobank of patient-derived tumour organoids has been developed to map genes that cancer cells depend on for growth and survival...