BioNews
Aneuploidy
An abnormal number of chromosomes, either too few or too many. Nearly all human body cells usually have a set of 46 chromosomes, while egg and sperm cells have 23.
123 articles
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Potential new treatment target for triple-negative breast cancer
A gene normally active only in reproductive cells may drive genetic instability in aggressive breast cancers, offering a potential new treatment target...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Why I think PGT-P should be legalised in the UK
Clinical embryologist and fertility clinic founder Dr Cristina Hickman shares her thoughts on preimplantation testing for polygenic traits ...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Gene variants identified that influence the risk of aneuploidy
Variants in maternal genes that increase the risk of aneuploidy have been identified...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
TV Review: Hitler's DNA – Blueprint of a dictator
Hitler's DNA has been identified and sequenced for the first time. Senior science writer, Dr Matteo Cortese, reviews a BBC programme investigating what the DNA reveals about Hitler's heritage – discussing the technology at its core: polygenic scores...
Image by Alan Handyside via the Wellcome Collection. Depicts equipment used for embryo biopsy.
Image by Alan Handyside via the Wellcome Collection. Depicts equipment used for embryo biopsy.
PGT-A as an IVF Add-On: 25 Years of Controversy
The second session of 'What Does Genomics Mean for Fertility Treatment?' – the 2025 Annual Conference of PET – explored controversies surrounding preimplantation genetic testing for aneuploidy...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
UK couples sending embryo data to USA for PGT-P
Some UK patients are seeking preimplantation genetic testing involving polygenic scores, placing fertility clinics in an awkward position...
Seeing the unseen: Live imaging of late-stage preimplantation human embryos
A novel method for visualising human blastocyst development – which has led to findings with implications for PGT-A – is described by Dr Ahmed Abdelbaki, a postdoctoral researcher in the Niakan Lab at the University of Cambridge...
PGT-A may overestimate impact of embryo abnormalities
A common IVF 'add-on' – preimplantation genetic testing for aneuploidy (PGT-A) – may overestimate the impact of embryo abnormalities, new research suggests...