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PETBioNewsGlossaryAneuploidy

BioNews

Aneuploidy

An abnormal number of chromosomes, either too few or too many. Nearly all human body cells usually have a set of 46 chromosomes, while egg and sperm cells have 23.

90 articles
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family (from Greek and Roman mythology) entwined in coils of DNA.
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family entwined in coils of DNA (based on the figure of Laocoön from Greek and Roman mythology).
News
20 June 2022 • 2 minutes read

US Supreme Court's reversal of Roe v Wade abortion law would endanger IVF

by Javier Bautista

Changes to US abortion law could have wide-ranging impacts on fertility treatment including IVF and preimplantation genetic diagnosis...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
News
20 June 2022 • 2 minutes read

Human gene-function map available to all scientists

by Dr Ara Schorscher-Petcu

Every single human gene has been linked to its function by scientists from the Massachusetts Institute of Technology, who have made the comprehensive gene-function map freely available to the scientific community...

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
20 June 2022 • 2 minutes read

Whole exome sequencing of mother could predict risk of creating embryos with aneuploidy

by Dr Malena Daich Varela

Variants in three genes have been linked to an increased risk of a woman creating aneuploid embryos while undergoing IVF and used to create a risk score using machine learning...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Comment
28 February 2022 • 6 minutes read

Lawfully running a red light: aneuploidy testing

by Julian Hitchcock

In a recent press statement on the use of preimplantation genetic testing of human embryos, the HFEA stated that 'Embryo selection is only legal in the UK to avoid serious inherited illnesses, usually by means of pre-implantation genetic diagnosis authorised by the HFEA, known as PGT-M or PGT-SR'…

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Comment
6 December 2021 • 4 minutes read

PGT-A in young, good prognosis populations

by Dr Eric J Forman

A recent large randomised trial published in the New England Journal of Medicine is receiving significant attention with clinicians who are critical of preimplantation genetic testing for aneuploidy (PGT-A) claiming it provides evidence that PGT-A does not improve IVF outcomes and should not be used outside of research settings…

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
26 November 2021 • 2 minutes read

PGT-A did not improve live birth rate in clinic trial

by Ruth Retassie

A recent study found that preimplantation genetic testing for aneuploidy may not improve live birth rate...

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
19 November 2021 • 2 minutes read

No difference in viability found between mosaic and non-mosaic embryos

by Tsvetana Stoilova

Many IVF embryos discarded due to chromosomal abnormalities could lead to viable pregnancies and healthy babies, a new non-selection clinical trial has suggested...

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
5 November 2021 • 2 minutes read

Embryonic stem cells can self-destruct when defective

by Beatrice Costa

Insight into genetic control of human embryonic stem cells' fate has offered new insight into cancer genetics and could inform future work in regenerative medicine...

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
Comment
11 October 2021 • 6 minutes read

Advances in Assisted Reproduction: What Can We Expect?

by Annabel Slater

Sarah Norcross, director of the Progress Educational Trust, invited the audience of the event to consider where assisted reproductive technologies stood 55 years ago...

Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1997. Depicts the gyri of the Thinker's brain as a maze of choices in biomedical ethics (based on Auguste Rodin's 'The Thinker').
CC BY 4.0
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1997. Depicts the gyri of the Thinker's brain as a maze of choices in biomedical ethics (based on the sculpture 'The Thinker' by Auguste Rodin).
News
1 October 2021 • 2 minutes read

Disparities in prenatal screening uptake revealed

by Tsvetana Stoilova

Non-invasive prenatal testing uptake in socioeconomically disadvantaged neighbourhoods of the Netherlands is significantly lower than in other parts of the country...

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