Non-invasive PGT-A did not improve pregnancy rates
A non-invasive form of PGT-A did not improve pregnancy rates in a clinical trial, but did reduce early miscarriages...
BioNews
Chromosome
Chromosomes are tightly packaged bundles of DNA, the chemical that encodes genetic information.
Most of the cells in a human body have a set of 46 chromosomes in their nucleus, while egg and sperm cells have only 23.
Separately, each of the mitochondria in each cell of a human body contain their own DNA, in the form of (multiple copies of) a circular chromosome.
672 articles
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
The Genetics of Infertility: Causes, Choices and Treatments
Genetic testing is beginning to identify causes of infertility that were previously unexplained. PET's latest event brought together clinicians and researchers to discuss the opportunities and limitations of reproductive genetics...
'Choosing not to look is not the same as not caring' – public attitudes to embryo selection
People's opinions on using preimplantation genetic testing for non-medical traits do not always reflect the decisions they make about selecting embryos when presented with the results...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Can PGT-A give us an accurate picture of the genetic content of embryos?
PGT-A is widely used to assess the chromosome status of IVF embryos, but how accurately can a biopsy of just a handful of cells predict an embryo's genetic makeup? Dr Desislava Staneva explains why interpreting PGT-A results is more complex than it may first appear...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Human genome benchmark maps both sets of chromosomes to fill gaps in genetic data
Scientists have obtained the most complete and accurate sequence of a human diploid reference genome to date, paving the way for advancements in personalised medicine...
Image by Alan Handyside via the Wellcome Collection. Depicts equipment used for embryo biopsy.
Expanding use of Singapore's CPF MediSave for IVF will yield diminishing returns
Dr Alexis Heng Boon Chin advises against using medical savings intended for old age to fund more fertility treatments...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Gene therapy vector DNA found integrated into patient's brain tumour
Adeno-associated virus gene therapy vector DNA has been found integrated within tumour tissue in a patient with Hurler syndrome who had been treated years earlier...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Potential new treatment target for triple-negative breast cancer
A gene normally active only in reproductive cells may drive genetic instability in aggressive breast cancers, offering a potential new treatment target...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
'Selfish chromosomes' influence which sperm cells survive
A gene that normally ensures sperm quality in fruit flies can be hijacked by 'selfish chromosomes' to bias inheritance, showing how some genetic elements determine which sperm survive...
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
More than 500 genes associated with uterine receptivity
Changes in the expression of 556 genes within uterine gland cells may explain why embryo implantation can fail repeatedly in some fertility patients...