ICSI and ovarian stimulation linked to different patterns in children's DNA
Parental age and various procedures used during assisted reproductive technology have been linked to different patterns of mutational changes in the DNA of offspring...
BioNews
170 articles
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
An ancient viral system sheds light on the origins of CRISPR
The discovery of a new gene-targeting system used by viruses to fend off competitors gives a glimpse into the possible evolutionary origin of CRISPR, and may offer new opportunities for genome editing technologies...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Base editing clarifies risks of genome editing in human embryos
Base editing can efficiently alter the DNA of human embryos, but it can also result in unintended genomic changes....
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Human genome benchmark maps both sets of chromosomes to fill gaps in genetic data
Scientists have obtained the most complete and accurate sequence of a human diploid reference genome to date, paving the way for advancements in personalised medicine...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Child dies after experimental genome editing in China
A six-year-old girl has died following an experimental genome editing treatment, prompting an investigation into the clinical trial by the university involved...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
Base editing in human embryos: Why patient voices matter
Behind every scientific breakthrough is a story. Dr Oliver Bower, the lead author of a recent Nature study, describes how listening to people affected by genetic disease reshaped his research and his perspective on the future of genome editing...
Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
Transformative embryo research: Who gets to contribute?
A landmark study highlights the importance of donated embryos and gametes in reproductive research. Dr Valerie Shaikly argues that more patients should have the opportunity to donate...
Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
Base editing reveals gene essential for human embryo formation
Using base editing, a highly precise method of genome editing, scientists have investigated the role of the NANOG gene in human embryos for the first time with this approach...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Improved CRISPR base editing therapy cuts high cholesterol
A CRISPR genome editing therapy provides sustained reductions in 'bad' cholesterol in people with inherited high cholesterol or premature coronary artery disease, an early-stage clinical trial shows...