A laboratory technique that uses fluorescent-labelled pieces of DNA to detect specific genes, chromosome segments or chromosomes, in cells examined under a special microscope.
In a recent press statement on the use of preimplantation genetic testing of human embryos, the HFEA stated that 'Embryo selection is only legal in the UK to avoid serious inherited illnesses, usually by means of pre-implantation genetic diagnosis authorised by the HFEA, known as PGT-M or PGT-SR'…
A personal memoir and tribute to Professor Joy Delhanty. Mentor, scientist, friend...
A new algorithm can map three-dimensional patterns of gene expression...
A seemingly brilliant hypothesis of preimplantation genetic screening arose in the 1990s when Dr Yuri Verlinsky proposed using polar body biopsies to detect chromosomal abnormalities in embryos prior to transfer in IVF...
Healthy embryos are discarded
It is clear from the reply of Mertes et al in BioNews 835 to the COGEN Consensus Statement on preimplanation genetic screening that some controversy still remains regarding the benefits of PGS...
The European Society of Human Reproduction and Embryology (ESHRE) has published an updated set of best practice guidelines for fertility clinics on the use of preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS) techniques...
Preimplantation genetic screening (PGS) for aneuploidy was first reported by Verlinsky et al (1995) and Munne et al (1995). Both of these initial studies analysed polar bodies. The aim of the technique is to help determine the best IVF embryo for transfer on the grounds of the polar body or embryo's chromosomes, by performing biopsy and analysis of the chromosomes using fluorescent in situ hybridisation (FISH). There have been hundreds of papers on the use of PGS. It is well known that for pa...
Make a habit of two things - to help, or at least to do no harm' (Attr Hippokrates of Kos). The principle of preimplantation testing for sporadic chromosome aneuploidy (preimplantation genetic screening, PGS) to improve the reproductive efficiency of assisted conception for couples at increased risk is a sound one. It...
New recommendations for prenatal screening programmes to detect Down syndrome could lead to some chromosome abnormalities being missed, UK researchers say. A team based at Salisbury District Hospital looked at the likely effect of the proposal to scrap a type of testing called karyotyping in favour of newer, rapid methods...
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