Making deliberate alterations to the DNA sequence at targeted locations in the genome. This can include deleting, inserting or replacing sections of DNA. Several approaches can be used to achieve these changes including zinc finger nucleases (ZFNs), TALENs, CRISPR/Cas and base editing.
A new CRISPR-based approach has been designed to selectively eliminate human cells with disease-causing genes in vitro...
A newly described neurodevelopmental disorder has been linked to changes in a small noncoding gene...
An artificial intelligence model trained on genomic data can predict disease-causing mutations and design synthetic viruses...
Metabolic disorders can seem forbiddingly complex, but a simplified approach to explaining their biological basis can lead to improved understanding, earlier diagnosis and better management, argues Dr Srividya Sreekantam...
A lipid nanoparticle-based gene therapy for cystic fibrosis restores biological function in a preclinical model...
A topical CRISPR-based genome-editing therapy has been developed to address disease-causing mutations responsible for inherited human skin disorders...
Not all mutations in the CTNNB1 gene — a key cancer driver — are equal, offering insights for personalised cancer treatment...
Professor Jim Al-Khalili interviews Professor George Church in this episode of The Life Scientific. From bringing back mammoths to the Human Genome Project... but does he ask probing enough questions? Davy Tennison finds out for BioNews...
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