Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
BioNews
Genome editing
Making deliberate alterations to the DNA sequence at targeted locations in the genome. This can include deleting, inserting or replacing sections of DNA. Several approaches can be used to achieve these changes including zinc finger nucleases (ZFNs), TALENs, CRISPR/Cas and base editing.
544 articles
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
King's birthday honours recognise experts in embryology and genetics
Former consultant embryologist Jane Blower was recognised in this year's King's Birthday Honours List alongside Professors Andrew Mumford, Bruce Whitelaw and Gareth Evans...
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family (from Greek and Roman mythology) entwined in coils of DNA.
New FDA guidance may speed up gene therapy development
The US Food and Drug Administration has proposed allowing manufacturers of cell and gene therapies to make use of existing scientific and platform knowledge during product development...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Improved CRISPR base editing therapy cuts high cholesterol
A CRISPR genome editing therapy provides sustained reductions in 'bad' cholesterol in people with inherited high cholesterol or premature coronary artery disease, an early-stage clinical trial shows...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Genome-edited stem cells support safer targeted therapy in blood cancers
A transplant of genome-edited stem cells designed to protect healthy donor cells from cancer therapy has shown promise in patients with aggressive blood cancers...
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family (from Greek and Roman mythology) entwined in coils of DNA.
UK regulator launches consultation on redefining gene therapy
The Medicines and Healthcare products Regulatory Agency has opened a UK-wide consultation on proposed changes to the legal definition of gene therapy medicinal products...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Clinical trial success moves first in-body CRISPR therapy toward FDA approval
A single-dose CRISPR-based genome-editing therapy for hereditary angioedema has shown positive Phase 3 clinical trial results and entered a step-by-step approval process with US regulators...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
CRISPR/Cas12a2 selectively destroys diseased human cells
A new CRISPR-based approach has been designed to selectively eliminate human cells with disease-causing genes in vitro...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Recessive gene variant causes neurodevelopmental disorder
A newly described neurodevelopmental disorder has been linked to changes in a small noncoding gene...