Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
BioNews
Genome editing
Making deliberate alterations to the DNA sequence at targeted locations in the genome. This can include deleting, inserting or replacing sections of DNA. Several approaches can be used to achieve these changes including zinc finger nucleases (ZFNs), TALENs, CRISPR/Cas and base editing.
524 articles
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Genes linked to brain development revealed by CRISPR genome editing
A large-scale study has unveiled genes essential for early brain development and uncovered the cause of a previously unrecognised neurodevelopmental disorder...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Patients disease-free after base editing gene therapy for aggressive leukaemia
Eleven people with aggressive T-cell leukaemia have now received a 'base editing' therapy, with seven remaining in remission up to three years after treatment...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
CRISPR therapies show promise for sickle cell and thalassaemia in younger children
Data on the effectiveness and safety of Casgevy gene therapy in children aged five to 11 years has been reported...
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
Gene essential for producing functional sperm explored
Disruption to a gene causes malformations to the development of sperm tails, resulting in mice producing no functional sperm...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Chemotherapy resistance in solid tumours overcome with CRISPR
CRISPR-based genome editing has been used to overcome chemotherapy resistance in lung tumours by disabling a tumour-specific mutation...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
New prime editing approach could potentially treat multiple genetic diseases
A new multipurpose genome editing approach could address around a third of rare genetic diseases...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Genome editing therapy cuts cholesterol in half, suggests clinical trial
A genome editing therapy robustly reduces harmful cholesterol levels in patients, according to data released from a Phase I clinical trial...