ICSI and ovarian stimulation linked to different patterns in children's DNA
Parental age and various procedures used during assisted reproductive technology have been linked to different patterns of mutational changes in the DNA of offspring...
BioNews
44 articles
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Base editing clarifies risks of genome editing in human embryos
Base editing can efficiently alter the DNA of human embryos, but it can also result in unintended genomic changes....
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Can PGT-A give us an accurate picture of the genetic content of embryos?
PGT-A is widely used to assess the chromosome status of IVF embryos, but how accurately can a biopsy of just a handful of cells predict an embryo's genetic makeup? Dr Desislava Staneva explains why interpreting PGT-A results is more complex than it may first appear...
Image by Alan Handyside via the Wellcome Collection. Depicts equipment used for embryo biopsy.
Expanding use of Singapore's CPF MediSave for IVF will yield diminishing returns
Dr Alexis Heng Boon Chin advises against using medical savings intended for old age to fund more fertility treatments...
Event Review: Testing Embryos – How far should we go?
The first in a series of discussions on human reproduction from the Hastings Centre for Bioethics asks today's most pressing questions about embryo selection…
Seeing the unseen: Live imaging of late-stage preimplantation human embryos
A novel method for visualising human blastocyst development – which has led to findings with implications for PGT-A – is described by Dr Ahmed Abdelbaki, a postdoctoral researcher in the Niakan Lab at the University of Cambridge...
PGT-A might reduce unsuccessful embryo transfers in over 35s
Genetic testing of IVF embryos could help more women over 35 have a baby in less time, according to a small study focused exclusively on women aged 35-42...
Image by Alan Handyside via the Wellcome Collection. Depicts equipment used for embryo biopsy.
Non-judicious uptake of PGT-A in Malaysia is driven by sociocultural factors
Associate professor of biomedical science at Peking University, China, Dr Alexis Heng Boon Chin, discusses the rise in preimplantation genetic testing for aneuploidy in Malaysia...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Errors and variations found in the genomes of individual human cells
Mutations in the human genome occur more often than previously expected, but are not deemed harmful, according to a new study...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Ethics of germline genome editing to prevent genetic diseases from an Islamic perspective
Dr Sayyed Mohamed Muhsin and Dr Alexis Heng Boon Chin give an ethical analysis of germline genome editing to prevent genetic diseases based on Islamic legal maxims (Qawaid Fiqhiyyah)...