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PETBioNewsGlossaryPGT (preimplantation genetic testing)

BioNews

PGT (preimplantation genetic testing)

A group of techniques that look at the genetic material of embryos created through IVF. These include:

PGT-A: preimplantation genetic testing for aneuploidy – also known as PGS (preimplantation genetic screening)

PGT-M: preimplantation genetic testing for monogenic conditions – also known as PGD (preimplantation genetic diagnosis)

PGT-SR: preimplantation genetic testing for structural chromosome rearrangements

18 articles
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family (from Greek and Roman mythology) entwined in coils of DNA.
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family entwined in coils of DNA (based on the figure of Laocoön from Greek and Roman mythology).
News
20 June 2022 • 2 minutes read

US Supreme Court's reversal of Roe v Wade abortion law would endanger IVF

by Javier Bautista

Changes to US abortion law could have wide-ranging impacts on fertility treatment including IVF and preimplantation genetic diagnosis...

Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
CC BY 4.0
Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
Comment
13 June 2022 • 5 minutes read

Fertility Frontiers: What Is a 'Permitted' Embryo in Law?

by Dr Antony Starza-Allen

The question of what is a 'permitted embryo' under the legislation governing assisted reproduction in the UK has received increasing scrutiny as technological progress challenges the concept of embryohood...

Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family (from Greek and Roman mythology) entwined in coils of DNA.
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family entwined in coils of DNA (based on the figure of Laocoön from Greek and Roman mythology).
News
29 April 2022 • 1 minute read

Couple sue Colorado fertility clinic over loss of embryos

by Sarah Pritchard

A US couple is suing an IVF clinic for destroying seven embryos by not storing them correctly...

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
24 March 2022 • 2 minutes read

Preimplantation genetic testing proposed to predict risk of common diseases

A new study claims to be able to map the genomes of embryos created by IVF, and suggests the technique could be used for preimplantation genetic testing...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Comment
21 March 2022 • 4 minutes read

PGT-P? Why using polygenic risk scores to select embryos is bad science

by Francesca Forzano

Preimplantation genetic testing can be used in IVF to assess and select the genotype of embryos in order to avoid passing specific genetic disorders on to future children...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Comment
28 February 2022 • 6 minutes read

Lawfully running a red light: aneuploidy testing

by Julian Hitchcock

In a recent press statement on the use of preimplantation genetic testing of human embryos, the HFEA stated that 'Embryo selection is only legal in the UK to avoid serious inherited illnesses, usually by means of pre-implantation genetic diagnosis authorised by the HFEA, known as PGT-M or PGT-SR'…

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
Comment
31 January 2022 • 8 minutes read

Adding Up What We Know: A Global Perspective on Fertility Treatment Add-Ons

by Sarah Norcross

There has been much professional and public debate about the use of so-called fertility treatment 'add-ons' over the years...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Comment
6 December 2021 • 4 minutes read

PGT-A in young, good prognosis populations

by Dr Eric J Forman

A recent large randomised trial published in the New England Journal of Medicine is receiving significant attention with clinicians who are critical of preimplantation genetic testing for aneuploidy (PGT-A) claiming it provides evidence that PGT-A does not improve IVF outcomes and should not be used outside of research settings…

Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
CC0 1.0
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
News
26 November 2021 • 2 minutes read

PGT-A did not improve live birth rate in clinic trial

by Ruth Retassie

A recent study found that preimplantation genetic testing for aneuploidy may not improve live birth rate...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Comment
12 November 2021 • 4 minutes read

A 'serious' threshold for genomic technologies – context counts!

by Marie-Christine Roy and 3 others

The determination of how 'serious' a condition is has direct and important implications for policy and clinical translation of existing and emerging genomic technologies...

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