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PETBioNewsGlossaryPGT (preimplantation genetic testing)

BioNews

PGT (preimplantation genetic testing)

A group of techniques that look at the genetic material of embryos created through IVF. These include:

PGT-A: preimplantation genetic testing for aneuploidy – also known as PGS (preimplantation genetic screening)

PGT-M: preimplantation genetic testing for monogenic conditions – also known as PGD (preimplantation genetic diagnosis)

PGT-SR: preimplantation genetic testing for structural chromosome rearrangements

18 articles
Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
Comment
13 June 2022 • 5 minutes read

Fertility Frontiers: What Is a 'Permitted' Embryo in Law?

by Dr Antony Starza-Allen

The question of what is a 'permitted embryo' under the legislation governing assisted reproduction in the UK has received increasing scrutiny as technological progress challenges the concept of embryohood...

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Comment
28 February 2022 • 6 minutes read

Lawfully running a red light: aneuploidy testing

by Julian Hitchcock

In a recent press statement on the use of preimplantation genetic testing of human embryos, the HFEA stated that 'Embryo selection is only legal in the UK to avoid serious inherited illnesses, usually by means of pre-implantation genetic diagnosis authorised by the HFEA, known as PGT-M or PGT-SR'…

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Comment
6 December 2021 • 4 minutes read

PGT-A in young, good prognosis populations

by Dr Eric J Forman

A recent large randomised trial published in the New England Journal of Medicine is receiving significant attention with clinicians who are critical of preimplantation genetic testing for aneuploidy (PGT-A) claiming it provides evidence that PGT-A does not improve IVF outcomes and should not be used outside of research settings…

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.
Comment
12 November 2021 • 4 minutes read

A 'serious' threshold for genomic technologies – context counts!

by Marie-Christine Roy and 3 others

The determination of how 'serious' a condition is has direct and important implications for policy and clinical translation of existing and emerging genomic technologies...