Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
BioNews
PGT (preimplantation genetic testing)
A group of techniques that look at the genetic material of embryos created through IVF. These include:
- PGT-M: preimplantation genetic testing for monogenic conditions (previously considered a form of PGD, or preimplantation genetic diagnosis)
- PGT-SR: preimplantation genetic testing for structural chromosome rearrangements (previously considered a form of PGD, or preimplantation genetic diagnosis)
- PGT-A: preimplantation genetic testing for aneuploidy (previously known as PGS, or preimplantation genetic screening)
- PGT-P: preimplantation genetic testing involving polygenic scores
85 articles
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family (from Greek and Roman mythology) entwined in coils of DNA.
PGT-P in the UK: The public needs more from the HFEA
'The current position, in which regulatory caution forecloses access to a technology that is already in routine clinical use in comparable jurisdictions, does not serve patients well and deserves scrutiny,' writes Dr Cristina Hickman...
Spotting the zebras among the horses: Understanding metabolic disorders
Metabolic disorders can seem forbiddingly complex, but a simplified approach to explaining their biological basis can lead to improved understanding, earlier diagnosis and better management, argues Dr Srividya Sreekantam...
Event Review: Testing Embryos – How far should we go?
The first in a series of discussions on human reproduction from the Hastings Centre for Bioethics asks today's most pressing questions about embryo selection…
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Why I think PGT-P should be legalised in the UK
Clinical embryologist and fertility clinic founder Dr Cristina Hickman shares her thoughts on preimplantation testing for polygenic traits ...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Why PGT-P is not lawful in the UK: The regulator explains
PGT-P is not supported by evidence and may reduce the chances of having a baby overall, argues HFEA chief executive Peter Thompson...
Polygenic embryo screening: The tension between choice and acceptance
Dr Dorit Barlevy looks at the various ethical considerations for prospective parents and clinicians considering using PGT-P...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Book Review: The Social Genome – The new science of nature and nurture
Are we on a path predetermined by the genes we inherit, or are we a product of the social environment with which we interact? Dr Helen Robertson reviews the new book written by sociologist Professor Dalton Conley...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Non-coding gene discovered to be a cause of blindness
New genetic causes of inherited blindness have been discovered that may offer answers to families with unexplained vision loss...