Non-invasive PGT-A did not improve pregnancy rates
A non-invasive form of PGT-A did not improve pregnancy rates in a clinical trial, but did reduce early miscarriages...
BioNews
PGT (preimplantation genetic testing)
A group of techniques that look at the genetic material of embryos created through IVF. These include:
- PGT-M: preimplantation genetic testing for monogenic conditions (previously considered a form of PGD, or preimplantation genetic diagnosis)
- PGT-SR: preimplantation genetic testing for structural chromosome rearrangements (previously considered a form of PGD, or preimplantation genetic diagnosis)
- PGT-A: preimplantation genetic testing for aneuploidy (previously known as PGS, or preimplantation genetic screening)
- PGT-P: preimplantation genetic testing involving polygenic scores
91 articles
'Choosing not to look is not the same as not caring' – public attitudes to embryo selection
People's opinions on using preimplantation genetic testing for non-medical traits do not always reflect the decisions they make about selecting embryos when presented with the results...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Can PGT-A give us an accurate picture of the genetic content of embryos?
PGT-A is widely used to assess the chromosome status of IVF embryos, but how accurately can a biopsy of just a handful of cells predict an embryo's genetic makeup? Dr Desislava Staneva explains why interpreting PGT-A results is more complex than it may first appear...
Podcast Review: Your Best Baby
A review of the podcast Your Best Baby examines the growing commercialisation of PGT-P and the ethical questions raised by selecting embryos based on predicted traits and disease risks...
Image by Alan Handyside via the Wellcome Collection. Depicts equipment used for embryo biopsy.
Expanding use of Singapore's CPF MediSave for IVF will yield diminishing returns
Dr Alexis Heng Boon Chin advises against using medical savings intended for old age to fund more fertility treatments...
Most IVF add-ons ineffective or lack evidence
Most common IVF add-ons lack strong evidence of proven benefits for patients, an extensive meta-analysis of trusted studies has shown...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Image by Bill Sanderson via the Wellcome Collection, © Wellcome Trust Ltd 1990. Depicts Laocoön and his family (from Greek and Roman mythology) entwined in coils of DNA.
PGT-P in the UK: The public needs more from the HFEA
'The current position, in which regulatory caution forecloses access to a technology that is already in routine clinical use in comparable jurisdictions, does not serve patients well and deserves scrutiny,' writes Dr Cristina Hickman...
Spotting the zebras among the horses: Understanding metabolic disorders
Metabolic disorders can seem forbiddingly complex, but a simplified approach to explaining their biological basis can lead to improved understanding, earlier diagnosis and better management, argues Dr Srividya Sreekantam...