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PETBioNewsNewsGene mutation gives mice 'night munchies'

BioNews

Gene mutation gives mice 'night munchies'

Published 23 May 2014 posted in News and appears in BioNews 755

Author

Siobhan Chan

Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
CC BY 4.0
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the sequencing output from an automated DNA sequencing machine.

Genes responsible for night eating syndrome, where eating patterns are out of sync with sleeping schedules, have been found in a study on mice...

Genes responsible for night eating syndrome, where eating patterns
are out of sync with sleeping schedules, have been found in a study on mice.

The research identifies a pair of genes that link eating
habits to the body clock. Mutations in the PER2 gene have long been known to affect
sleeping habits. Scientists investigating its sister gene, PER1, found that mice genetically engineered to have a defective copy of the gene were much more
prone to eating when they should be sleeping.

'In the mice without PER1, there
was no obvious defect in their sleep-wake cycles', said study author Dr Satchidananda Panda from
the Salk Institute, California, USA. 'Instead, when we looked at their
metabolism, we suddenly saw drastic changes'.

While mice with the PER2 mutation went to sleep at an
earlier time, mice with the PER1 gene mutation overate and gained more weight when
eating normal food. They also put on weight much more quickly when given a
high-fat diet.

'We really never expected that we
would be able to decouple the sleep-wake cycle and the eating cycle, especially
with a simple mutation', said Dr Panda. 'It opens up a whole lot of future
questions about how these cycles are regulated'.

The researchers believe that
normally, the PER1 and PER2 genes are switched on and off at the same time, so
that sleeping and eating patterns are in sync. But a mutation in PER1 means
that this mechanism becomes misaligned, so the urge to eat strikes at odd
hours.

When the team only gave the mice
access to food at normal mealtimes, they found that they were able to maintain
a normal weight. This means that the weight gain was due to the time that the
meals were eaten rather than being a direct result of the mutation itself.

One to two
percent of people are thought to have the syndrome, which has recently been
classified as a type of eating disorder.

'For a
long time, people discounted night eating syndrome as not real', said Dr Panda.
'These results in mice suggest that it could actually be a genetic basis for
the syndrome'.

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