BioNews
BRCA2
A gene on human chromosome 13, which instructs the cell to make a protein that normally helps to repair damaged DNA and suppress cell growth. A person who inherits certain mutations in a BRCA2 gene has a higher risk of getting breast cancer, ovarian cancer and certain other types of cancer.
Genetic mechanisms link egg ageing and cancer risk
A genomic study has identified five gene variants associated with earlier menopause and increased risk of cancer...
The wrong genes for the job?
The British Army's initial decision to preclude an applicant from joining due to a family history of BRCA variant-related cancer raises a number of questions about how employers collect and use genetic data…
BRCA2 variant found in people of Shetland heritage
One in 40 people who have four grandparents from the Isle of Whalsay in Shetland, Scotland, carry a gene variant known to increase their risk of developing cancer...
Patients' DNA sequences predict future breast cancer characteristics
Researchers have discovered a potential mechanism underpinning why a person's genome might influence the subtype of breast cancer they develop...
Breast cell map reveals unique changes in BRCA risk variant carriers
The world's largest catalogue of human breast cells has revealed early cell changes in carriers of BRCA gene mutations, offering a potential target for breast cancer prevention...
BRCA testing offered to people of Jewish heritage
People with Jewish ancestry, who are more likely to carry a genetic risk of developing some cancers, will be offered genetic testing through a new programme announced by the NHS in England...
NICE recommends olaparib for the treatment of ovarian and prostate cancer
The National Institute for Health and Care Excellence has recommended the NHS funds olaparib for the maintenance treatment of advanced ovarian cancer in women with BRCA1 and 2 variants and advanced or metastatic prostate cancer in men...
Podcast Review: The Gift – Health
The BBC Radio 4 podcast series explores the aftermath of different individual's decision to take an at-home DNA test...
Polygenic scores perform poorly in predicting common diseases
Polygenic risk scores perform poorly if used to predict common diseases such as coronary artery disease or breast cancer, a University College London study has found...