A change in the sequence of DNA. Mutations occurring in genes may prevent them from working properly, which might result in disease (a genetic condition). Mutations occur naturally at a low rate, but can also be induced by radiation and some chemicals.
A genome editing technique has corrected a disease-causing mutation in blood stem cells taken from a patient with a rare and severe immune disorder...
NHS England plans to roll out a new rapid genomic test developed by the University of Nottingham to diagnose brain tumours...
Chronic cigarette smoke exposure may change lung stem cells in ways that influence which types of lung cancer develop when cancer-driving genetic alterations occur...
Parental age and various procedures used during assisted reproductive technology have been linked to different patterns of mutational changes in the DNA of offspring...
A Phase 2/3 trial assessing a gene therapy for X-linked retinitis pigmentosa (XLRP) shows significant improvements in low-light vision...
Genetic testing is beginning to identify causes of infertility that were previously unexplained. PET's latest event brought together clinicians and researchers to discuss the opportunities and limitations of reproductive genetics...
Children who have received platinum-based chemotherapy carry a distinct mutational signature in their livers as a result, as well as a higher level of mutations across various healthy tissues...
A CRISPR-based therapy continues to reduce harmful cholesterol levels in patients after a one-year follow-up in a Phase 1 clinical trial...
Sperm from a Danish donor carrying a genetic variant classified as 'likely pathogenic' was used by 39 women in Belgium to conceive 53 children...
Phase 3 trial results for an experimental vaccine based on mRNA technology indicate positive initial outcomes for treating high-risk melanoma patients, potentially representing the arrival of a unique form of cancer therapy...
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