PGT-A may overestimate impact of embryo abnormalities
A common IVF 'add-on' – preimplantation genetic testing for aneuploidy (PGT-A) – may overestimate the impact of embryo abnormalities, new research suggests...
BioNews
Chromosome
Chromosomes are tightly packaged bundles of DNA, the chemical that encodes genetic information.
Most of the cells in a human body have a set of 46 chromosomes in their nucleus, while egg and sperm cells have only 23.
Separately, each of the mitochondria in each cell of a human body contain their own DNA, in the form of (multiple copies of) a circular chromosome.
672 articles
Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour).
Eggs created from human skin cells and then fertilised
Egg cells have been created from human skin cell DNA, which have then been fertilised with sperm to create embryos...
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
Cannabis use may affect women's eggs
Cannabis may directly interfere with women's ability to conceive by affecting the health of their eggs...
Image by Sílvia Ferreira, Cristina Lopo and Eileen Gentleman via the Wellcome Collection. Depicts a single human stem cell embedded within a porous hydrogel matrix (false colour).
Spaceflight may cause blood stem cells to age faster
Human blood stem cells appear to age faster in space, a new study has found...
PGT-A might reduce unsuccessful embryo transfers in over 35s
Genetic testing of IVF embryos could help more women over 35 have a baby in less time, according to a small study focused exclusively on women aged 35-42...
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
Human eggs acquire fewer mutations with age than previously thought
Human eggs appear to be protected from the age-related accumulation of genetic mutations in mitochondrial DNA (mtDNA)...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Polygenic scores and PGT-P: Lost in translation?
Dr Emma Meaburn explains what polygenic scores are, and what they can and cannot tell us about a person's risk of – or resilience to – a complex trait...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Most complete overview of the human genome revealed
Synergistic evidence from two studies published in Nature this week have updated our understanding of the human genome...
Image by Alan Handyside via the Wellcome Collection. Depicts a human egg soon after fertilisation, with the two parental pronuclei clearly visible.
Sperm RNA may predict embryo quality
Small RNA molecules in sperm are important for embryo development and may act as biomarkers for sperm and embryo quality, a new study has shown...
Image by the University of Edinburgh via the Wellcome Collection. Depicts cells with organelles (colour-enhanced electron micrograph of cells, showing nuclei in green and mitochondria in red).
The third parent
Following the news that healthy children have been born in the UK following mitochondrial donation IVF, Professor Rachel Bowlby explains why so-called 'three-parent babies' are nothing new...