Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
BioNews
CRISPR
Clustered regularly-interspaced short palindromic repeats.
Naturally occurring in bacteria, segments of DNA used for defence against pathogens.
Used by humans in genome editing: the CRISPR/Cas system used to edit DNA at specific locations in the genome.
303 articles
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
CRISPR cholesterol therapy continues to lower LDL levels after one year
A CRISPR-based therapy continues to reduce harmful cholesterol levels in patients after a one-year follow-up in a Phase 1 clinical trial...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Podcast Review: The Joy of Why – What's the future of gene editing?
Dr Tom Turner explores Professor Jennifer Doudna's reflections on the discovery of CRISPR and the future of genome editing in this conversation, which examines one of the most transformative advances in modern biology…
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Tumour organoid biobank maps gene dependencies in multiple cancers
A comprehensive biobank of patient-derived tumour organoids has been developed to map genes that cancer cells depend on for growth and survival...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Image by K Hardy via the Wellcome Collection. Depicts a human embryo at the blastocyst stage (about six days after fertilisation) 'hatching' out of the zona pellucida.
Base editing in human embryos: Why patient voices matter
Behind every scientific breakthrough is a story. Dr Oliver Bower, the lead author of a recent Nature study, describes how listening to people affected by genetic disease reshaped his research and his perspective on the future of genome editing...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Improved CRISPR base editing therapy cuts high cholesterol
A CRISPR genome editing therapy provides sustained reductions in 'bad' cholesterol in people with inherited high cholesterol or premature coronary artery disease, an early-stage clinical trial shows...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
Clinical trial success moves first in-body CRISPR therapy toward FDA approval
A single-dose CRISPR-based genome-editing therapy for hereditary angioedema has shown positive Phase 3 clinical trial results and entered a step-by-step approval process with US regulators...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
CRISPR/Cas12a2 selectively destroys diseased human cells
A new CRISPR-based approach has been designed to selectively eliminate human cells with disease-causing genes in vitro...