Clustered regularly-interspaced short palindromic repeats.
Naturally occurring in bacteria, segments of DNA used for defence against pathogens.
Used by humans in genome editing: the CRISPR/Cas system used to edit DNA at specific locations in the genome.
A genetic variant linked to Alzheimer's disease impairs the production of the fatty layer that insulates neurons by disrupting an important signalling pathway...
The discovery of a new gene-targeting system used by viruses to fend off competitors gives a glimpse into the possible evolutionary origin of CRISPR, and may offer new opportunities for genome editing technologies...
A CRISPR-based therapy continues to reduce harmful cholesterol levels in patients after a one-year follow-up in a Phase 1 clinical trial...
Dr Tom Turner explores Professor Jennifer Doudna's reflections on the discovery of CRISPR and the future of genome editing in this conversation, which examines one of the most transformative advances in modern biology…
A comprehensive biobank of patient-derived tumour organoids has been developed to map genes that cancer cells depend on for growth and survival...
Behind every scientific breakthrough is a story. Dr Oliver Bower, the lead author of a recent Nature study, describes how listening to people affected by genetic disease reshaped his research and his perspective on the future of genome editing...
A CRISPR genome editing therapy provides sustained reductions in 'bad' cholesterol in people with inherited high cholesterol or premature coronary artery disease, an early-stage clinical trial shows...
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