Donor Conception and Genetic Disease: Lessons to Be Learned from Donor 7069
Seven experts discussed the sensitive case of donor 7069 and explored what could be done to avoid it happening again, as well as how to improve outcomes if it did...
BioNews
Mutation
A change in the sequence of DNA. Mutations occurring in genes may prevent them from working properly, which might result in disease (a genetic condition). Mutations occur naturally at a low rate, but can also be induced by radiation and some chemicals.
1434 articles
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
FDA opens path to approval for Hunter syndrome gene therapy
The US Food and Drug Administration is allowing biotech company Regenxbio to reapply for licensing of a gene therapy for Hunter syndrome, in a reversal of its previous decision...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Ebola virus continues active replication in brain tissue models
Three-dimensional cerebral organoids suggest that Ebola virus can establish long-term infection in the human brain...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Grief, genetics and the IVF funding gap
After losing two daughters to a rare inherited genetic condition, David and Juliette discuss what they believe is a gap in NHS IVF policy, sharing their family's story to raise awareness and help others who are facing similar challenges...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Abnormal protein activity may contribute to DNA damage in cancer cells
Overproduction of a DNA repair protein called EXO1 can trigger DNA damage and increase chemotherapy sensitivity in human cancer cells, a new study has reported...
Image by Christoph Bock/Max Planck Institute for Informatics via Wikimedia Commons. Depicts a DNA molecule that is methylated on both strands on the centre cytosine.
Inflammation may cause lasting epigenetic changes in blood stem cells
Blood stem cells can retain a long-term 'memory' of inflammatory events, which may help explain links between ageing, chronic disease and blood cancers...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
UK approves topical gene therapy for 'butterfly children'
A novel topical gene therapy for the treatment of a rare genetic skin disorder has been approved by the Medicines and Healthcare products Regulatory Agency...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Gene therapy vector DNA found integrated into patient's brain tumour
Adeno-associated virus gene therapy vector DNA has been found integrated within tumour tissue in a patient with Hurler syndrome who had been treated years earlier...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
CRISPR/Cas12a2 selectively destroys diseased human cells
A new CRISPR-based approach has been designed to selectively eliminate human cells with disease-causing genes in vitro...