ICSI and ovarian stimulation linked to different patterns in children's DNA
Parental age and various procedures used during assisted reproductive technology have been linked to different patterns of mutational changes in the DNA of offspring...
BioNews
48 articles
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
AI atlas models the effects of nine billion DNA variants
A new AI-powered database predicts the effects of single-nucleotide changes in any of the three billion bases in human DNA...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Synthetic cell feeds, grows and divides
A synthetic cell created entirely from non-living chemical components can grow, replicate its genetic material and divide, completing the typical life cycle of a cell in the laboratory...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
AI model predicts rare, disease-causing genetic variants
An artificial intelligence model has been developed to identify unseen disease-causing genetic variants and rank their severity, according to a new study...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Human genome structure mapped at base-pair resolution
The 3D structure of the human genome has been mapped at the level of individual bases, defining complex structures which control how DNA functions within the cell...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
CRISPR base editing reduces DNA repeats that cause Huntington's and Friedreich's ataxia
Genome editing has been used to disrupt a type of repetitive DNA sequence that is found in certain genes and can cause severe neurological disease...
Image by Matthew Daniels via the Wellcome Collection. Depicts human cells, showing the stages of cell division.
CRISPR base editing corrects mutation that causes lung disease
A genome editing approach has been used to correct a disease-causing genetic variation in people, for the first time...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Inherited cancer risk linked to single-nucleotide DNA differences
Single-nucleotide differences in a DNA sequence that are associated with an inherited cancer risk have been identified through a large-scale screening study...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
AI creates synthetic genetic sequences and genome editing system
An artificial intelligence model has been developed that is capable of decoding genomes and designing synthetic DNA, RNA and proteins...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Gene variants influencing DNA methylation affect expression
The link between DNA sequences, DNA methylation and gene expression has been elucidated using a new technique that can detect the level of methylation at different points on the DNA...