RNA-based control switch could be used to turn on gene therapies in cells
A new technique to turn therapeutic genes on in specific cells has been developed, potentially changing the future of gene therapies...
BioNews
Off-target effects
Unintended changes to a genome, away from the desired target site, which occur as a consequence of genome editing.
56 articles
New method giving insight into DNA repair pathways could improve genome editing
In-depth mapping of DNA repair mechanisms of the double-stranded and single-stranded breaks required for genome editing, could enhance the efficacy of these approaches, new research has revealed...
Prenatal base editing corrects lysosomal storage disease
Base editing, a form of genome editing, has been used in preclinical model to correct a lysosomal storage disease known as Hurler syndrome...
Researchers warn of unintended effects from CRISPR genome editing
Using CRISPR/Cas9 genome editing in human embryos may introduce 'on-target' errors...
Base editing offers hope for child ageing disease
A type of genome editing had been used in mice to treat the symptoms of progeria, a fatal premature ageing disease in children...
New study on CRISPR: the stake of unintended consequences in embryos
CRISPR-based genome editing has revolutionised molecular life sciences, however the ISSCR provides guidelines for responsible and ethical research to achieve safe and effective use...
Podcast Review: Mapping Humanity — How modern genetics is changing criminal justice, personalised medicine, and our identities
Facilitating productive discussion between scientists, policymakers, and the public surrounding genetic technologies, and their applications, is more crucial than ever...
CRISPR genome editing improved by enzyme testing
The safety and efficiency of CRISPR genome editing can be improved by identifying the best genome editing option for a specific application...
New report gives guidance on genome editing for heritable diseases
Genome editing is not yet safe for creating germline changes in humans, an international commission has concluded...
Image by Peter Artymiuk via the Wellcome Collection. Depicts the shadow of a DNA double helix, on a background that shows the fluorescent banding of the output from a DNA sequencing machine.
Genome editing in human embryos has unintended side-effects
CRISPR genome editing may result in unwanted heritable genetic changes, which could lead to long-term risks in a clinical context...