CRISPR Associated Proteins are enzymes that associate with CRISPR RNAs to bind to and alter DNA or RNA target sequences.
Cas enzymes originate in bacteria and as such a wide variety of types exist. Some are used for genome editing or editing RNA.
There are also versions that have been altered in the lab to perform specific tasks. Common examples include Cas9 which makes a double-stranded break in a target DNA sequence, and Cas13 which targets RNA.
A CRISPR-based form of genome editing that can replace entire genes may offer a new way to treat some genetic diseases...
A newly described CRISPR-associated protein can kill infected cells by cutting all types of DNA and RNA...
Mouse heart cells, genetically modified after a heart attack, recovered from the damage caused...
A 13-year old girl has received the first ever 'base editing' therapy, in which cells were genetically modified to fight her otherwise incurable leukaemia...
CRISPR has been used to eliminate the toxic protein build-up associated with Huntington's disease in mice...
The safety and efficiency of CRISPR-based genome editing may be improved by using an enzyme that cuts just one strand of DNA instead of both...
Full-term mouse offspring were derived from single unfertilised eggs using targeted CRISPR/Cas9 epigenome editing...
The first team to use CRISPR to edit a disease-causing gene in humans has found the effects are persistent up to a year later...
A hidden component of the CRISPR/Cas3 genome editing system, which is essential for it to work, has been discovered by scientists...
Researchers have developed several new CRISPR techniques to modify the genomes of bacterial populations on a large scale...
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